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Drug Abuse and Dependency of Adderall


Adderall is listed by the U.S. Drug Enforcement Administration (DEA) as a Schedule II controlled substance, with Schedule I as the worst drug and a Schedule V controlled substance possessing the least problems. It can only be used in prescription form in the U.S. The United Nations also lists Adderall as a Schedule II controlled substance. Canada lists Adderall as a Schedule I controlled drug and substance that can only be obtained through a prescription. Japan and South Korea prohibit Adderall. Thailand lists Adderall as a Type 1 narcotic. Travelers entering New Zealand must declare Adderall. It will be taken away and put in a dispensary, where daily amounts can be retrieved by the visitor.

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Using Adderall for a long period of time can lead to addiction. When amphetamines are abused for extended periods, amphetamine psychosis sets in, a condition that can also be triggered by a continuous usage of Adderall in smaller doses. Amphetamine psychosis includes disorderly thought, delusions, sight and sound hallucinations, and when severe, puts patients into a catatonic state.

Additional signs of amphetamine psychosis include vomiting, tremors, a lack of sleep, seizures, agitation, fast breathing, nausea, hyperthermia, high blood pressure, diarrhea, dilated pupils, an irregular heartbeat and aggression. Recurring amphetamine psychosis can be set off by taking a very small dosage of Adderall for anyone who was once addicted to the drug. The treatment of amphetamine psychosis involves adequately drinking liquids, keeping the heart rate, blood pressure and body temperature at normal levels and allowing the drug to work its way out of the body.

There is a strong history of drug abuse with amphetamines. Since Adderall gives the person taking it a sense of well-being and alertness, it creates a “high” that is attractive. Some “street” names for Adderall include beanies, Christmas trees, uppers, speed, pep pills, dexies, black beauties and beans. Excessive psychological dependence results from using this drug over a long period of time. Some addicts increase levels of Adderall to levels much greater than what is recommended.

Amphetamine abuse comes in the form of inhaling crushed powder or mixing the powder with water and injecting it into the blood stream with hypodermic needles. This procedure is dangerous, since fillers that can’t dissolve are present in Adderall tablets, which can create a blockage of small blood vessels.

Abusing Adderall is a dangerous activity. Studies involving high doses of amphetamine in lab animals indicate that it poisons the dopamine pathways in the brain, which leads to permanent, yet not irreversible, brain damage. Extreme doses of amphetamine lead to life-threatening hormonal levels that can result in heart attacks or strokes, repetitive tics and body movements and a rapid breakdown of muscle tissue.

A sudden termination of the drug after taking it at high levels brings on bouts of intense exhaustion, depression and changes in electric brain waves while sleeping. Intense addiction to amphetamines results in changes in personality, times of hyperactivity, noticeable irritability, a high level of insomnia and critical cases of inflammations along the skin. The most severe instances of drug abuse related to amphetamines result in a psychosis resembling schizophrenia.

Long-term amphetamine addicts experience withdrawal symptoms that are severe within 24 hours after their last dosage. This includes cravings, fatigue, excessive daytime sleepiness (EDS), extreme and often unpleasant dreams, agitation, anxiety, irritability, depression and a state of feeling unhappy. Thoughts of suicide can surface. Some of these symptoms last for a week and a smaller degree of symptoms occur for up to two weeks after that. Sometimes, antidepressant drugs are prescribed to amphetamine addicts who are experiencing withdrawal symptoms.


Precautions in Using Adderall


Adderall shouldn’t be taken with Vitamin C or fruit juices, which tend to slow down the absorption of the drug. Any urinary acidifying agent, such as sodium acid phosphate or ammonium chloride, increase the concentration of Adderall and shouldn’t be used with the drug. The same phenomenon occurs with stomach alkalinizing agents, such as sodium bicarbonate and stomach antacids.

The use of Adderall can result in a slight dizzy sensation, thereby impairing the ability of someone to successfully drive a motor vehicle. Anyone taking Adderall should inform their doctor before having surgery.

If you are allergic to sympathomimetic drugs, such as epinephrine, with brand names of Medihaler-Epi, Adrenaclick, Twinject and EpiPen; or pseudoephedrine, also called Wal-Phed, Suphedrine, SudoGest and Sudafed; or if you have other allergies, consult with a physician before taking Adderall, since inert ingredients in the drug may cause an allergic reaction.

Caution should be exercised when taking Adderall with antidepressants known as monoamine oxidase inhibitors (MAOIs), such as iproniazid, with brand names of Rivivol, Ipronin, Ipronid, Iprazid, Euphozid, Genopharm and Marsilid; selegiline, also known as Zelapar, Eldepryl and Emsam, L-deprenyl and Anipryl; and phenalzine, which is also called Nardelzine and Nardil. When Adderall is taken within two weeks of any MAOI drug, there is a high risk of a hypertension crisis, which means critical impairment of the central nervous system, the cardiovascular system and the renal system are possible, resulting in irreversible organ damage.

A risk of serotonin syndrome is possible when Adderall is mixed with selective serotonin reuptake inhibitors (SSRIs). Some SSRI drugs include paroxetine, also called Brisdelle, Sereupin, Seroxat, Pexeva, Paxil and Aropax; citalopram, with brand names of Cipramil and Celexa; and fluxoxamine, named as Luxox, Floxyfal and Uvox. Serotonin syndrome involves severe dizziness, muscle twitches, fever, a loss of coordination and a fast heartbeat. It can be fatal if left untreated.

Since both Adderall and norepinephrine reuptake inhibitors (NRIs) are drugs that boost the fight-or-flight hormone of norepinephrine or noradrenaline, caution should be taken mixing these two drugs. An example of an NRI drug is atomoxetine, also called Attentin, Tomoxetlin and Strattera.

Caution should be used when mixing buproprion, an antidepressant and anti-smoking medication that is also called Voxra, Zyban, Aplenzin, Elontril, Prexaton, Budeprion and Wellbutrin, with Adderall. Both drugs are enhancing the same areas of the brain which could lead to a greater risk of convulsions.
When Adderall is mixed with a monoaminergic tricyclic antidepressant (TCA), it can create pain when urinating, result in glucose in the urine, cause dilated pupils, lead to a nauseous feeling and vomiting, result in vertigo, anxiety, severe headache and nervousness.

Serious side effects (see Adderall Side Effects listed above) can result when Adderall is taken with any CYP2D6 (liver enzyme) inhibitors, since they can lead to higher levels of amphetamine in the body. Drugs included in this category are bupropion (see two paragraphs earlier), most SSRIs (see four paragraphs earlier), some anti-pscychotic drugs like levomepromazine, sold as Levoprome, Nozinan and Nosinan; haloperidol, also called Sigaperidol, Serenace, Peluces, Linton, Keselan, Halosten, Haldol, Eukystol, Einalon S, Duraperidol, Dozic, Brotopon, Bioperidin and Aloperidin; and thioridazine, with brand names of Thioril, Novoridazine and Mellaril; cocaine, and methadone.

Antihistamines should not be taken with Adderall, since the drug can counteract the sedative effect of antihistamines. Those with a history or existing conditions of cardiac issues or mental illness should not take Adderall. Sudden death, heart attacks and strokes are possible with patients who have a history of heart-related problems.

People who have a history of psychiatric problems are urged to restrain from taking Adderall. For these people, taking this medication can result in dangerous or new thought problems and behavior. Patients who have a bipolar disorder may see a degradation of the condition by taking Adderall. Also, new or intensified hostility and aggressive behavior can occur for people with psychiatric issues after taking Adderall.


Also, anyone who has abused drugs should not take Adderall. The U.S. Food and Drug Administration (FDA) lists Adderall as an FDA pregnancy category C, which means it’s been demonstrated to have an unfavorable effect on the fetus in animal studies.